| ARF-GEF基因家族的研究进展 |
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| 引用本文： | 刘士平,王璐,薛艳红,寿惠霞. ARF-GEF基因家族的研究进展[J]. 遗传, 2009, 31(10): 982-992. DOI: 10.3724/SP.J.1005.2009.00982 |
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| 作者姓名： | 刘士平 王璐 薛艳红 寿惠霞 |
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| 作者单位： | 1. 浙江大学生命科学学院植物生理学与生物化学国家重点实验室, 杭州 310058;2. 三峡大学化学与生命科学学院, 宜昌 443002 ; |
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| 基金项目： | 国家重点基础研究发展基金(973计划)项目，家博士点专项基金项目 |
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| 摘 要： | ARF-GEFs是小G蛋白ADP核糖基化因子(ADP-ribosylation factor, ARF)的鸟苷酸交换因子(Guanine- nucleotide exchange factor, GEF), 在所有真核生物中, 大型ARF-GEF都是高度保守的。它在生物体的膜泡分拣和蛋白运输中发挥着重要作用, 近年来关于ARF-GEFs的蛋白结构、亚细胞定位和相关功能的报道很多, 它已成为细胞生物学领域的一大研究热点。文章主要介绍了大型ARF-GEF的蛋白结构和在不同物种中的分布, 阐述了该基因家族在酵母、人和拟南芥中的相关进展, 并对其调控机理进行了小结。
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| 关 键 词： | 高尔基体 小泡运输 发育 蛋白分拣 ARF-GEF |
| 收稿时间： | 2009-03-31 |
| 修稿时间： | 2009-05-18 |
Research progress in ARF-GEF gene family |
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| LIU Shi-Ping,WANG Lu,XUE Yan-Hong,SHOU Hui-Xia. Research progress in ARF-GEF gene family[J]. Hereditas, 2009, 31(10): 982-992. DOI: 10.3724/SP.J.1005.2009.00982 |
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| Authors: | LIU Shi-Ping WANG Lu XUE Yan-Hong SHOU Hui-Xia |
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| Affiliation: | 1. State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science, Zhejiang University, Hangzhou 310058, China; 2. College of Chemistry and Life Science, Three Gorges University, Yichang 443002, China ; |
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| Abstract: | ARF-GEFs are a family of guanine-nucleotide exchange factors catalyzing the exchange of GDP for GTP on ADP-ribosylation factor. Large ARF-GEFs are highly conserved in all eukaryotes. It is an important regulator in both membrane dynamics and protein trafficking. Significant progress has been made in elucidating the structure, subcellular localization, and physiological functions of ARF-GEFs as a hot topic of cell biology recently. In this review, the characteristics and distribution of ARF-GEFs in different species, and recent research progress of ARF-GEFs and their regulation system are summarized. |
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| Keywords: | ARF-GEF |
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