Synthesis and superoxide dismutase-like activity of new manganese(III) complexes based on tridentate N2O ligands derived from histamine |
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| Authors: | Federico Cisnetti Clotilde Policar |
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| Affiliation: | a Équipe de Chimie Bioorganique et Bioinorganique, Institut de Chimie Moléculaire et de Matériaux d’Orsay, UMR CNRS 8182, Université Paris XI, 91405 Orsay Cedex, France
b Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Viale G.P.Usberti 17A, Universitá di Parma, 48100 Parma, Italy |
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| Abstract: | We have obtained two new manganese(III) complexes based on tridentate ligands bearing imidazole and phenol moieties. The structure of the chosen ligands favored the Mn(III) oxidation state due to the compatibility of the geometry of the complexes with a Jahn-Teller tetragonal distortion, as was shown by X-ray diffraction for one of the complexes. This induced a lowering of the oxidation potential for the Mn(III)/Mn(II) couple, which can be correlated to the superoxide dismutase-like (SOD-like) activity of the complexes, compared with a previously published Mn(III) complex. |
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| Keywords: | Manganese(III) SOD mimic Histamine Electrochemistry Tetragonal distortion N2O ligand |
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