Cyclophilin A and viral infections |
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Authors: | Daijun Zhou Qiang Mei Jintao Li Haiyang He |
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Institution: | 4th Team of Cadet Brigade, Third Military Medical University, Chongqing 400038, PR China. |
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Abstract: | Cyclophilin A (CyPA) is a peptidyl-prolyl cis/trans isomerase originally identified as the target of the immunosuppressive drug cyclosporine A. A number of reports have demonstrated that CyPA plays a critical role in the successful replication of viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), etc. However, recent studies demonstrated that CyPA also possesses a repressive effect on the replication of some viruses like Influenza A virus and rotavirus. Moreover, CyPA could also regulate host IFN-I response to viral infections. Together, these evidences showed diverse roles of CyPA in viral infection. |
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