THERPA: A small molecule database related to prion protein regulation and prion diseases progression |
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| Authors: | Sol Moe Lee Wonseok Lee Yeong Seon Lee Jin-Soo Yoo Soo-Jung Park |
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| Affiliation: | 1. Division of Bacterial Disease Research, Center for Infectious Diseases Research, Korea National Institute of Health, Centers for Disease Control &2. Prevention, Cheongju-si, Chungcheongbuk-do, South Korea;3. Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, South Korea;4. Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, South Korea;5. Division of Bio-Medical Informatics, Center for Genome Science, Korea National Institute of Health, Centers for Disease Control & |
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| Abstract: | Prion diseases are fatal neurodegenerative disorders that affect humans and animals. Although various small molecules have been evaluated for application in the treatment of prion diseases, none have been shown to be efficacious. Expanding our knowledge of these molecules is important for understanding of the complex mechanisms of prion diseases. To improve access to the scattered information on small molecules related to prion diseases, we built a database of therapeutic molecules associated with prion diseases (THERPA, therpa.pythonanywhere.com). THERPA includes 119 small molecules and their 283 relationships with prion diseases. THERPA is an interactive visual database and useful for improving search efficiency which can help researchers identify intrinsic small molecules that can be used for developing therapeutics for prion diseases. |
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| Keywords: | Prion Prion diseases small molecules THERPA Database |
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