Changes in mouse brain diazepam receptor binding after phenobarbital administration |
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| Authors: | B R Sonawane S J Yaffe B H Shapiro |
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| Institution: | 1. Departments of Pediatrics and Pharmacology University of Pennsylvania, School of Medicine, The Children''s Hospital of Philadelphia, USA;1. Department of Animal Biology School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA 19104, USA |
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| Abstract: | Specific 3H-diazepam binding was measured in adult mouse (strain, Crl=CD-1) brain after four days of an inductive dose of phenobarbital pretreatment (i.p.). Sexual dimorphism was observed in 3H-diazepam brain binding, female mice had significantly higher benzodiazepine binding than males without any differences in apparent affinity constants (KD). Phenobarbital pretreatment caused a significant decrease in the maximal number of binding sites (Bmax) as well as in dissociation rate constants in both sexes. |
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