Hepatic redox state: attenuation of the acute effects of ethanol induced by chronic ethanol consumption |
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| Authors: | S Domschke W Domschke C S Lieber |
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| Affiliation: | 1. Department of Medicine (Prof. Ludwig Demling), University of Erlangen-Nuremberg, D8520 Erlangen, West Germany;2. Section of Liver Disease and Nutrition, Bronx Veterans Administration Hospital and Mount Sinai School of Medicine of the City University of New York, N.Y., U.S.A. |
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| Abstract: | The effects of an acute dose of a diet containing ethanol (3g/kg) on hepatic redox state was compared in rats fed ethanol for 25 days and in their littermates given isocaloric carbohydrate. In both groups, cytoplasmic and mitochondrial redox states of pyridine nucleotides shifted to a more reduced level, but the changes were much less extensive in rats chronically fed ethanol. This metabolic adaption may reflect the oxidation of ethanol by a pathway not involving alcohol dehydrogenase, such as the microsomal ethanol osidizing system, which increases in activity after chronic ethanol ingestion. |
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