|
|||||
|
|
Pyridoxal 5'-phosphate as a catalytic and conformational cofactor of muscle glycogen phosphorylase B |
|
| Authors: | Livanova N B Chebotareva N A Eronina T B Kurganov B I |
| Institution: | (1) Bach Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 119071, Russia |
| Abstract: | This review summarizes data on structure of muscle glycogen phosphorylase b and the role of the cofactor pyridoxal 5"-phosphate in catalysis and stabilizing the native conformation of the enzyme. Specific attention is paid to the stabilizing role of pyridoxal 5"-phosphate upon denaturation of phosphorylase b. Stability of holoenzyme, apoenzyme, and enzyme reduced by sodium borohydride is compared. |
| Keywords: | glycogen phosphorylase b mechanism of reaction pyridoxal 5"-phosphate regulation thermal inactivation quaternary structure |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |