Prenatal diagnosis of congenital anomalies in an intrauterine growth retarded fetus |
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Authors: | Mitchell S Golbus Bryan D Hall Robert K Creasy |
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Institution: | (1) Department of Obstetrics and Gynecology, University of California School of Medicine, San Francisco;(2) Department of Pediatrics, University of California School of Medicine, San Francisco;(3) the Cardiovascular Research Institute, University of California School of Medicine, San Francisco |
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Abstract: | Summary Chromosome analysis of amniotic fluid cells and amniotic fluid alpha-fetoprotein determinations were used to investigate a fetus with severe intrauterine growth retardation in the third trimester. The karyotype was 47,XY,18+ and increased alpha-fetoprotein levels indicated the presence of congenital malformations. We suggest that when severe fetal growth retardation is detected early in the antepartum course, amniotic fluid alpha-fetoprotein and amniotic fluid cell chromosome studies be done to determine if congenital anomalies may be an etiological factor. |
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