| 两个人组蛋白H1基因的亚克隆和它们启动子核苷酸顺序的比较 |
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| 引用本文： | 仲如.两个人组蛋白H1基因的亚克隆和它们启动子核苷酸顺序的比较[J].中国生物化学与分子生物学报,1986,2(2):59-64. |
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| 作者姓名： | 仲如 |
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| 作者单位： | 中国科学院生物物理研究所 北京 |
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| 摘 要： | 从人基因库中分离得到的两个含有不同变种组蛋白H_1基因的λ克隆(λHh8和λHh9),分别把它们含有该基因的片段(8c和9a)插入载体puc8质粒中,得到了亚克隆pHh8c和pHh9a。对这两个人组蛋白H_1基因的启动子(Promoter)和部份编码蛋白质的区域作了核苷酸顺序的分析和比较,确定了它们的启动要素和同系顺序。
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| 关 键 词： | 组蛋白基因 基因克隆 启动子核苷酸顺序 |
| 收稿时间： | 1986-04-20 |
TWO SUBCLONES OF HUMAN HISTONE H1 GENES AND COMPARISON OF THEIR PROMOTER SEQUENCES |
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| Zheng,Ru.TWO SUBCLONES OF HUMAN HISTONE H1 GENES AND COMPARISON OF THEIR PROMOTER SEQUENCES[J].Chinese Journal of Biochemistry and Molecular Biology,1986,2(2):59-64. |
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| Authors: | Zheng Ru |
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| Institution: | (Institute of Biophysics,Academia Sinica Beijing |
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| Abstract: | Two subclones (pHh8c and pHh9a) were obtained by inserting 8c and 9a DNA fragments containing human histone H1 gene into cloning vector pUC8.Comparison of their 5'-flankjng sequences has revealed some promoter elements and consensus sequence motifs,the Hogness box TATA at position-85,the CCAAT sequences at -105,the GC rich regions and TC pyrimidine clusters. |
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| Keywords: | Histone gene gene cloning promoter sequence |
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