C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators,and enhances many axon guidance defective mutants |
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| Authors: | Catarina Mörck Vivekanand Vivekanand Gholamali Jafari Marc Pilon |
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| Affiliation: | (1) Department of Cell and Molecular Biology, University of Gothenburg, S-405 30 Gothenburg, Sweden;(2) Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA |
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| Abstract: | Background Teneurins are transmembrane proteins that assist morphogenetic processes in many organisms. ten-1 is the C. elegans teneurin homolog with two transcripts, ten-1a and ten-1b, that respectively encode a long (TEN-1L) and short (TEN-1S) form of the protein. We previously isolated a C. elegans mutant where one pharyngeal neuron was frequently misplaced, and now show that it corresponds to a novel allele of ten-1. |
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