Effect of Intralipid-infusion on erythrocyte membrane in rabbits |
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| Authors: | M Goto R Kawada T Sekiya K Ohki K Sakata Y Nozawa |
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| Affiliation: | 1. IFSTTAR, MAST, GPEM, F-44344 Bouguenais, France;2. GeoTechLab, Department of Civil, Architectural and Environmental Engineering, University of Padova, Via Ognissanti 39, 35129 Padova, Italy;3. APTLab, Advanced Particle Technology Laboratory, Department of Industrial Engineering, University of Padova, Via Marzolo 9, 35131 Padova, Italy;1. School of Environment, Resources and Sustainability, University of Waterloo, Waterloo, Ontario, Canada;2. Department of Biology, Trent University, Peterborough, Ontario K9J 7B8, Canada;3. Forensic Science Program, Trent University, Peterborough, Ontario K9J 7B8, Canada |
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| Abstract: | Through Intralipid infusion in rabbits, the phospholipids derived from Intralipid were incorporated into erythrocytes, although Intralipid is mainly composed of triglycerides. This is supported by the increase in oleic acid and the compensatory decrease in linoleic acid of the phospholipids in the erythrocyte membrane, corresponding to the content of linoleic acid in the phospholipids from Intralipid. The excess phospholipid rendered the membrane more fluid, probably by overwhelming the rigidifying effect of the increased cholesterol content. Furthermore, the shape of erythrocytes was changed from biconcave to spur, dose dependently. The morphological alterations in erythrocyte membranes could not be completely elucidated by the changes in lipid. These results suggested that the alteration in lipid metabolism in Intralipid-infused rabbits caused various effects on the erythrocyte membrane, through the elevation of triglyceride, cholesterol, and phospholipid contents in plasma. |
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