Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse Chromosomes 1, 4, and 11 |
| |
Authors: | Kari Buck Pamela Metten John Belknap John Crabbe |
| |
Institution: | (1) Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, and Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA, US |
| |
Abstract: | Barbiturate dependence is associated with the development of physiological dependence (withdrawal), tolerance, or a maladaptive
pattern of drug use. Analysis of strain and individual differences with animal models for physiological dependence liability
are useful means to identify potential genetic determinants of liability in humans. Behavioral and quantitative trait locus
(QTL) mapping analyses were conducted with mice that are resistant versus sensitive to pentobarbital withdrawal. With a multi-stage
genetic mapping strategy, a pentobarbital withdrawal QTL (Pbw1) was mapped to the distal region of mouse Chromosome (Chr) 1 and may be identical to an alcohol withdrawal QTL mapped to
this chromosomal region. Two suggestive QTLs for pentobarbital withdrawal, both in proximity to QTLs definitely mapped for
alcohol withdrawal, were also tentatively identified. These were on Chr 11 in proximity to a gene cluster including several
members of the GABAA receptor gene family, and on Chr 4 near a locus associated with β-carboline-induced seizure severity. These data represent
the first detection and mapping of loci influencing risk for physiological dependence on barbiturates, and suggest the involvement
of common genes in physiological dependence on pentobarbital and alcohol.
Received: 14 October 1998 / Accepted: 19 January 1999 |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|