In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides |
| |
Authors: | Devienne Karina F Raddi MariaStellaG Varanda Eliana A Vilegas Wagner |
| |
Affiliation: | Instituto de Química de Araraquara, SP, Brazil. |
| |
Abstract: | Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy-1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromelioides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|