中国不同人群的红细胞抗原多态性及血型组合

计算了汉、回、蒙古、维吾尔、侗、高山、朝鲜和壮等八个民族红细胞抗原常见等位基因数、常见血型和血型组合频率、血型相同的二人随机相遇的概率、血型组合数、常见和罕见的血型组合、AB、Rh(D-)型频率及排除亲子关系的概率。结果表明,中国北方民族的血型系统的多态程度比南方民族高。

RED CELL ANTIGEN POLYMORPHISMS AND BLOOD GROUP COMBINATIONS IN DIFFERENT ETHNIC GROUPS OF CHINA

The Han, Hui, Mongolian, Uygur, Dong, Gaoshan, Korean and Zhuang ethnic groups were studied with regard to their red cell antigen polymorphisms and blood group combinations. The Han and ethnic groups of North China have more common alleles than the ethnic groups of South China do, and among Northern ethnic groups the Uygur has the largest number of common alleles. These differences mainly deal with the Rhesus, MNSs, Ktll and Lutheran blood groups systems. The most common blood combinations and their frequencies are listed as follows. Han: O, MNss, CCDee, P( ), Fy(a b-), Jk(a b ), Di(a-), Le (a-),K(-) Lu(a-), Xg(a ) 0.0070 Hui:O,MNss, CCDee, P(-), FY(a b-), Jk(a b ), Di(a-), Le(a-), K(-), Lu(a-), Xg(a ) 0.0062 Mongolian: O, MNss, CCDee, P(-),Fy (a b-), Jk (a b ), Di(a-), Le(a-), K(-),Xg(a ) 0.0059 Uygur: B, MNss, CCDee, P( ),Fy (a b-), Jk(a-b ), Di(a-),K(-), Lu(a-), Xg(a-) 0.0025 Dong: O, MNss, CCDee, P(-), Fy(a b-), Jk(a b ), Di(a-), Le(a-), Xg(a-) 0.0053 Gaoshan: 0, Mss, CCDee, P(-), Fy(a b-), Jk(a b ), Di(a-), K(-), Lu(a-), Xg(a-) 0.0079 Korean: A, MNss, CCDee, P(-),Fy (a b-), Jk (a b ), Di(a-),K(-),0.0182 Zhuang: O, Mss, CCDee, P(-), Fy(a b-), Jk(a b ), Di(a-), K(-), 0.0485 The probabilities that two randomly selected individuals would be found to have same combination of phenotypes of 11 systems are less than 1 in 2500 for Uygur, 1 in 800 for Han, Hui and Mongolian, 1 in 500 for Gaoshan and 1 in 290 for Dong. The Korean and Zhuang ethnic groups have been examined for 8 blood groups. Their probabilities for two randomly selected individuals having the same combination are less than 1 in 250 and 70, respectively. The probabilities of AB, EH (D-) combination are 2.9% for Han, 4.8% in Hui, 3.2% in Mongolian, 39.7% in Uygnr, 0% in Dong, 0.2% in Gaoshan, 0.9% in Zhuang and 4.8% in Korean, respectively. The probabilities of exclusion of paternity with 11 blood groups are 59.28% for Han, 63.26% in Hui, 70.60% in Uygur and 57.13% in Gaoshan ethnic groups. This propabi-lity for 10 blood groups is 60.66% in Mongolian, and that for 9 blood groups is 55.03% in Dong. And those for 8 blood groups are 55.86% in Korean and 47.39% in Zhuang. It may be concluded that the extent of the blood group polymorphism in the ethnic groups of North China is greater than that of Southern ethnic groups.