Cytotoxic effects of C-glycosides in HOS and HeLa cell lines |
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| Authors: | Sanhueza Carlos A Mayato Carlos Machín Rubén P Padrón José M Dorta Rosa L Vázquez Jesús T |
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| Affiliation: | Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, La Laguna, Tenerife, Spain. |
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| Abstract: | Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI(50) values) below 10 microM, the C-glucopyranoside 38 being the most active against HeLa (5.4 microM) and the dichlorocyclopropyl derivative 42 against HOS (1.6 microM). Some preliminary structure-activity relationships were established. |
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