Wistar大鼠实验性动脉粥样硬化的研究

目的　使用普通级雄性Wistar大鼠灌胃给药 (L 蛋氨酸 )进行动脉粥样硬化模型的研究。方法　模型组分别给药 (L 蛋氨酸 ) 2 30mg 只 (A组 )和 4 5 0mg 只 (B组 )每隔 7天进行一次血脂检查及主动脉弓常规病理组织学检查。结果　服药后引起动物血脂紊乱 ,病理组织学检查服药 8周时实验A组与B组均见到主动脉弓局部内膜下水肿 ,同期B组 (高剂量组 )病理改变重于A组 (低剂量组 ) ,偶见泡沫细胞和单核细胞侵润。对照组无上述相关改变。结论　Wistar大鼠服用L 蛋氨酸一定时间后可引起血脂的紊乱及主动脉弓局部内膜下的病变

Preliminary Study on Experimental Atherosclerosis of Wistar Rat

Objective To develop the rat model of ordinary male Wistar Rat induced by filling with L methionine. Method The drug doses of group A and B were 230 mg/rat and 450 mg/rat respectively. The blood lipid level and pathology of aortic arch were examined every week. Results Taking L methionine resulted in the disturbance of blood lipid, and the local tunica edema of aortic arch in both group A and B at the 8th week after. The pathological change of group B (high dose group) was more severe than group A (low dose group), and occasionally the invasion of theca cells and mononuclear leukocytes could be seen. The control group had no changes mentioned above. Conclusion Filling with L methionine may cause disturbace of blood lipid and pathological changes of tunica intima of artery in Wistar Rat.