Immunocytochemical localization of calspectin (a non-erythroid spectrin-like protein) in thyroid glands of normal and TSH-treated rats |
| |
| Authors: | K Ishimura T Senda K Kitajima H Fujita Y Fujio K Sobue |
| |
| Institution: | (1) Department of Anatomy, Osaka University Medical School, 4-3-57 Nakanoshima, Kita-ku, 530 Osaka, Japan;(2) Department of Neurochemistry and Neuropharmacology, Osaka University Medical School, 4-3-57 Nakanoshima, Kita-ku, 530 Osaka, Japan |
| |
| Abstract: | Summary The localization of calspectin (fodrin, a nonerythroid spectrin-like protein), which is known to bind calmodulin and F-actin, was detected in the thyroid gland of normal and TSH-treated rats by means of light-microscopic immunocytochemistry. Calspectin was demonstrated in the cytoplasm of the follicle epithelial cells especially along the baso-lateral plasma membrane in normal rats. In TSH-treated animals, in addition to the baso-lateral plasma membrane region, the apical plasma membrane region of the follicle epithelial cells also showed positive reaction to the immunostaining. These results suggest that calspectin, in conjugation with calmodulin and actin, play a role in the secretory activities including reabsorption activity of colloid of the follicle epithelial cell.Supported by grants from the Ministry of Education, Science and Culture, Japan |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
