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Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors |
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| Authors: | Xu Jinyou Wei Lan Mathvink Robert J Edmondson Scott D Eiermann George J He Huaibing Leone Joseph F Leiting Barbara Lyons Kathryn A Marsilio Frank Patel Reshma A Patel Sangita B Petrov Aleksandr Scapin Giovanna Wu Joseph K Thornberry Nancy A Weber Ann E |
| Institution: | Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. Jinyou_Xu@merck.com |
| Abstract: | A novel series of oxadiazole based amides have been shown to be potent DPP-4 inhibitors. The optimized compound 43 exhibited excellent selectivity over a variety of DPP-4 homologs. |
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