首页 | 本学科首页   官方微博 | 高级检索  
     


Aligning two RNA secondary structures with l-block
Authors:Wang Zhuozhi  Tillier Elisabeth R M
Affiliation:Ontario Cancer Institute, University Health Network, Canada. zwang@uhnres.utoronto.ca
Abstract:RNA sequences can form structures which are conserved throughout evolution and the question of aligning two RNA secondary structures has been extensively studied. Most of the previous alignment algorithms require the input of gap opening and gap extension penalty parameters. The choice of appropriate parameter values is controversial as there is little biological information to guide their assignment. In this paper, we present an algorithm which circumvents this problem. Instead of finding an optimal alignment with predefined gap opening penalty, the algorithm finds the optimal alignment with exact number of aligned blocks.
Keywords:
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号