A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes |
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| Authors: | Kang Wu Wang Weiguo Zhi Xiaoxia Zhang Bo Wei Ping Xu Hongyan |
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| Institution: | Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210008, China. |
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| Abstract: | A very simple and cheap linker has been used for solid-phase synthesis of peptide aldehydes. Protected amino acid aldehydes are immobilized on 2-Cl(trt) resin as oxazolidine formation via diethanolamine. After classical Fmoc SPPS, treatment of the resin with AcOH/DCM/H(2)O (8:1:1) affords peptide aldehydes in high yield and purity. |
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