Large chromatin domains in pluripotent and differentiated cells |
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Authors: | Hu Shibin Cheng Lu Wen Bo |
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Institution: | Department of Biochemistry and Molecular Biology & Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, China. |
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Abstract: | Pluripotent stem cells are able to proliferate unlimitedly and to generate all somatic cell types, thus holding a great promise in medical applications. Epigenetic modifications are believed to play crucial roles in regulating pluripotency and differentiation. Recent genome-wide studies on mammalian systems have revealed several types of large chromatin domains which are associated with higher-order organization of the genome. The elucidation of genomic distribution and dynamics of these domains have shed light on the mechanisms underling pluripotency and lineage commitment. |
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