Prevention of fasting-mediated bone marrow atrophy by leptin administration |
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Authors: | Fujita Yoshimasa Yanagida Hidetoshi Mimori Tsuneyo Jin Zhe-Xiong Sakai Tomoyuki Kawanami Takafumi Sawaki Toshioki Masaki Yasufumi Fukushima Toshihiro Okazaki Toshiro Umehara Hisanori |
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Affiliation: | Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan. fujita-y@kanazawa-med.ac.jp |
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Abstract: | Leptin is an adipokine that regulates body weight. In the current study, we demonstrate that continuous injection of leptin prevents the lymphocyte reduction observed in fasted mice, especially the immature B cell populations in the bone marrow. Although leptin administration reduced apoptotic cells in the bone marrow of fasted mice, it did not prevent glucocorticoid-mediated apoptosis in vitro. Bone marrow atrophy has also been shown in the leptin receptor-deficient db/db mice. In order to investigate the mechanisms underlying these processes, we transplanted bone marrow cells from db/db or control (+m/+m) mice into C.B-17/lcr-scid/scid mice. We found that the spleen and bone marrow B cell populations were completely reconstituted when db/db and +m/+m cells were transplanted into scid mice. Our findings suggest that direct interactions between leptin and bone marrow cells are not essential for the development of B cells in a metabologically normal environment. |
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