| VersusSNP:一种单碱基突变的筛选及分类工具 |
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| 引用本文： | 梁群,王琪,张秀清,汪建. VersusSNP:一种单碱基突变的筛选及分类工具[J]. 生物信息学, 2010, 8(2): 150-152,155 |
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| 作者姓名： | 梁群 王琪 张秀清 汪建 |
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| 作者单位： | 1. 中国科学院北京基因组研究所,应用医学组,北京,101300;中国科学院研究生院,北京,100049
2. 中国科学院北京基因组研究所,应用医学组,北京,101300;深圳华大基因研究院,深圳,518083 |
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| 基金项目： | 国家高技术研究发展计划(863)重大专项资助项目 No. 2006AA02A301 |
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| 摘 要： | 单碱基突变的筛选和分类是SNP分析的基础。为解决手工进行突变位点挖掘工作的困难,编写了VersusSNP软件。它可以解析并过滤序列比对结果,并根据突变类型将位点加以分类,以图形界面呈现给用户。使用VersusSNP,用户可以直观地了解基因组中单碱基突变的情况。其程序及源代码可以从http://sourceforge.net/projects/versussnp下载。
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| 关 键 词： | 单碱基 点突变 替换 同义 非同义 插入 缺失 |
VersusSNP:A novel tool for mining and classifying single nucleotide mutations |
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| LIANG Qun,WANG Qi,ZHANG Xiu-qing,WANG Jian. VersusSNP:A novel tool for mining and classifying single nucleotide mutations[J]. Chinese Journal of Bioinformatics, 2010, 8(2): 150-152,155 |
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| Authors: | LIANG Qun WANG Qi ZHANG Xiu-qing WANG Jian |
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| Affiliation: | 1. Dept. of applied medical genomies, Beijing Institute of Genomics Chinese Academy of Sciences, Beijing 101300, China ; 2. Graduate University of the Chinese Academy of Sciences, Beijing 100049, China ; 3. Beifing Genomies Institute at Shenzhen, Shenzhen 518083 ,China) |
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| Abstract: | How to find and classify single nucleotide mutations is very important to SNP analysis. For remedying the shortcomings caused by mining mutations manually, we developed an application called VersusSNP, which classifies the mutations by filtering and parsing sequence alignments, then displays the results in a graphic interface. VersusSNP enables biologists to learn single nucleotide mutations in an intuitive manner. Its compiling and source code are freely available at http ：//sourceforge. net/projects/versussnp. |
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| Keywords: | single nucieotide base mutation substitution synonymous non - synonymous insertion deletion |
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