Substituted oxygenated heterocycles and thio-analogues: synthesis and biological evaluation as melatonin ligands |
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Authors: | Charton I Mamai A Bennejean C Renard P Howell E H Guardiola-Lemaître B Delagrange P Morgan P J Viaud M C Guillaumet G |
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Affiliation: | Institut de Chimie Organique et Analytique, associé au CNRS, Université d'Orléans, France. |
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Abstract: | A new series of substituted oxygenated heterocycles and thio-analogues were synthesized and evaluated as melatonin receptor ligands. The replacement of the indolic moiety of melatonin by heterocyclic skeleton such as 1,4-benzodioxin, 2,3-dihydro-1,4-benzodioxin, chroman, 2,3-dihydro-1,4-benzoxathiin, thiochroman, carrying the amidic chain on the aromatic ring, leads to compounds showing a weak affinity for melatonin receptors, except for the compounds 1cb and 1hb. |
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