Reduction of PrPC in human cerebrospinal fluid after spinal cord injury |
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| Authors: | Anna Carnini Steve Casha V Wee Yong R John Hurlbert and Janice EA Braun |
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| Institution: | 1 Hotchkiss Brain Institute; Department of Physiology and Pharmacology; University of Calgary; Calgary, AL CA ;2 Hotchkiss Brain Institute; Department of Clinical Neurosciences; University of Calgary; Calgary, AL CA |
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| Abstract: | It has been estimated that cerebrospinal fluid (CS F) contains approximately 80 proteins that significantly increase or decrease in response to various clinical conditions. Here we have evaluated the CS F protein PrPC (cellular prion protein) for possible increases or decreases following spinal cord injury. The physiological function of PrPC is not yet completely understood; however, recent findings suggest that PrPC may have neuroprotective properties. Our results show that CS F PrPC is decreased in spinal cord injured patients 12 h following injury and is absent at 7 days. Given that normal PrPC has been proposed to be neuroprotective, we speculate that the decrease in CS F PrPC levels may influence neuronal cell survival following spinal cord injury.Key words: CSF, PrPC, Hsp25, crystallin domain, spinal cord injury |
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