Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues |
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| Authors: | Caballero Esther Adeva Marta Calderón Suzanne Sahagún Heidi Tomé Fernando Medarde Manuel Fernández José Luis López-Lázaro Miguel Ayuso Maria Jesús |
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| Institution: | Laboratorio de Qui;mica Orgánica y Farmacéutica, Facultad de Farmacia, 37007, Salamanca, Spain. escab@usal.es |
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| Abstract: | An array of 4-(aryl or indolyl)pyrrolo3,4-c]carbazole-1,3-diones (open analogues of indolocarbazole alkaloids), 10-(aryl or indolyl)pyrrolo3,4-b]carbazole-1,3-diones, and different derivatives have been prepared using a Diels-Alder plus Fischer indolization approach and tested as cytotoxic agents. Some representative compounds display interesting cytotoxic profiles. |
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