Cofilin phosphatases and regulation of actin dynamics |
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Authors: | Huang Timothy Y DerMardirossian Céline Bokoch Gary M |
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Institution: | The Scripps Research Institute, Departments of Immunology and Cell Biology, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA. |
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Abstract: | Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances. |
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