Intestinally implanted Nippostrongylus brasiliensis adult worms decrease serum paraoxonase-1 activity in rats |
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| Authors: | Ayman Samir Farid Toshiyuki Shimohira Ikuo Kobayashi Juri Sawada Yoichiro Horii |
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| Institution: | 1. Department of Pathogen Biology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu, People''s Republic of China;2. Department of Pathology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, Nanjing 210011, Jiangsu, People''s Republic of China;3. Molecular Biology Lab, Wuxi Center for Disease Control and Prevention, Wuxi 214023, Jiangsu, People''s Republic of China;4. Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People''s Republic of China;1. Department of Immunology and Parasitology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan;2. Department of 2nd Pathology and Cell Biology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan;3. Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan;4. Animal Research Center, Tokyo Medical University, 6-1-1, Shinjuku, Shinjuku-ku, Tokyo 160-0022, Japan;1. Department of Psychobiology, Universidade Federal de São Paulo, Brazil;2. Department of Preventive Medicine, Universidade Federal de São Paulo, Brazil;1. Witold Stefański Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland;2. Division of Parasitology, Warsaw University of Life Sciences, 8 Ciszewskiego, 02-786 Warsaw, Poland |
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| Abstract: | We have previously reported a significant decrease in serum PON1 activity after Nippostrongylus brasiliensis infection in Wistar rats in association with the inflammatory response mounted against the parasite in the migratory phase of infection. However, the roles of intestinal phase and the associated oxidative stress during N. brasiliensis infection on PON1 activity have not yet been elucidated. In the present study, we observed a significant reduction in serum paraoxonase and arylesterase activity on days 6 and 9 post-implantation with N. brasiliensis adult worms in the absence of a significant increase in various serum pro-inflammatory cytokines. In addition, provision of the antioxidant butylated hydroxyanisole (BHA) to adult worm-implanted rats did not ameliorate the reduction in PON1 activity. Due to the prolonged intestinal phase of gastrointestinal nematode infections, alterations in PON1 activity during this phase need to be further examined to elucidate the mechanism of alteration in PON1 activity. |
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