Non-alcoholic steatohepatitis and animal models: Understanding the human disease |
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| Authors: | Marta Varela-Rey Nieves Embade Usue Ariz Shelly C. Lu José M. Mato M. Luz Martínez-Chantar |
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| Affiliation: | 1. CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Technology Park of Bizkaia, 48160 Derio, Bizkaia, Spain;2. Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University Southern California, Los Angeles, CA 90033, United States of America;1. Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan;2. Department of Urology, Changzhou Second Hospital, Nanjing Medical University, Nanjing, People''s Republic of China;1. Cleveland BioLabs, Inc., Buffalo, NY 14203, United States;2. MPI Research, Mattawan, MI 49071, United States;1. Department of Pediatrics, Stanford University, Stanford, California, USA;2. Department of Chemistry, Indiana University, Bloomington, Indiana, USA;1. Iran University of Medical Sciences, Tehran, Iran;2. Tehran University of Medical Sciences, Tehran, Iran;3. Shahid Sadughi University of Medical Science, Yazd, Iran;1. State Key Laboratory of Natural Medicines, Department of Biochemistry, China Pharmaceutical University, Nanjing 210009, China;2. Virginia Commonwealth University, Richmond, VA 23298, USA;3. Institute of Toxicology, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China |
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| Abstract: | Non-alcoholic fatty liver disease includes a broad spectrum of liver abnormalities ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma. Patients with primary NASH have the metabolic (or insulin resistance) syndrome, condition typically associated with obesity, diabetes, hyperlipidemia and hypertension. To understand the mechanisms implicated in development of NASH, animal models of non-alcoholic fatty liver disease have been generated. These have greatly improved our understanding of some of the aspects of this disease. The challenge now is to identify the common mechanisms between the animal models and humans, which could eventually lead to a better prognosis and development of novel therapeutic strategies. |
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