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Effects of acute hypoxia on the adenylate cyclase and evans blue transport of brain microvessels |
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| Authors: | G za d m, Ferenc Jo , P ter Temesv ri, Ern Dux,P ter Szerdahelyi |
| Affiliation: | a Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, University Medical School, Szeged, Hungary b Department of Pediatrics, University Medical School, Szeged, Hungary c Central Research Laboratory, University Medical School, Szeged, Hungary |
| Abstract: | Kinetic parameters of the albumin transport were measured during and after an acute hypoxic insult evoked in newborn piglets by experimental bilateral pneumothorax. Adenylate cyclase activity was determined in the cerebral microvessels isolated by ultracentrifugation from different stages of brain damage. A decrease of the adenylate cyclase activity was observed in the cerebral microvessels of animals with acute hypoxic condition. However, the adenylate cyclase activity was found to be increased significantly in the microvessels during recirculation. The activation of adenylate cyclase in the microvessel wall may be of pathogenetic importance in the development of vasogenic brain oedema. |
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