ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane |
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| Authors: | Yogesh C. Awasthi S. V. Singh H. Ahmad L. W. Wronski S. K. Srivastava E. F. LaBelle |
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| Affiliation: | (1) Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, 77550 Galveston, TX, USA |
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| Abstract: | We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione — xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes. |
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| Keywords: | glutathione xenobiotics erythrocytes membranes ATPase transport |
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