Left-right axis malformations in man and mouse |
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| Authors: | Casey B Hackett B P |
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| Affiliation: | Department of Pathology, Baylor College of Medicine, Texas Children's Hospital, Houston, 77030, USA. bcasey@bcm.tmc.edu |
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| Abstract: | The study of left-right axis malformations in man and mouse has greatly advanced understanding of the mechanisms regulating vertebrate left-right axis formation. Recently, the roles of the TGF-beta family, Sonic hedgehog and fibroblast growth factor signaling, homeobox genes, and cilia in left-right axis determination have been more clearly defined. The identification of genes and environmental factors affecting left-right axis formation has important implications for understanding human laterality defects. |
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