Antigen-reactive cell opsonization: a mechanism of antibody-mediated immune suppression. |
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| Authors: | I V Hutchinson H Zola |
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| Institution: | Department of Experimental Immunobiology, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, England |
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| Abstract: | Antisera against sheep red blood cells (SRBC) specifically suppressed the direct anti-SRBC plaque-forming cell (PFC) response in mice when passively administered with the antigen. The suppressive activity of mouse and rabbit anti-SRBC sera was found to correlate with anti-SRBC opsonic activity but not with hemagglutination or hemolysin titers. Macrophage depletion of mice, using carrageenan treatment, inhibited antibody-mediated immune suppression. When mice immunized with SRBC were given 125I-labeled Udr, radiolabeled spleen lymphocytes were obtained which specifically formed rosettes with SRBC. These radiolabeled antigen-reactive cells (1ARC) were specifically opsonized in mice treated with antigen-antibody complexes but not in mice treated with antigen or antibody alone. These results suggest that antibody-mediated immune suppression may be due to specific opsonization (and subsequent destruction) of ARC in the presence of antigen-antibody complexes. |
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| Keywords: | To whom all correspondence should be sent |
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