In vitro and in vivo inhibition by zopiclone of benzodiazepine binding to rodent brain receptors. |
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Authors: | J C Blanchard A Boireau C Garret L Julou |
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Institution: | Rhône-Poulenc Research, Centre Nicolas Grillet, Vitry-sur-Seine, F 94400, France |
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Abstract: | Up to now the only drugs known to be able to inhibit the binding of benzodiazepines to rodent brain receptors are members of this chemical family.Zopiclone (RP 27 267), a new drug with a pharmacological profile similar to that of chlordiazepoxide and nitrazepam but entirely different chemically from benzodiazepines, has been tested for its ability to inhibit benzodiazepine binding. and studies have shown that zopiclone is able to inhibit the binding of 3H] diazepam and 3H] flunitrazepam to brain receptors. The potency of zopiclone is quite comparable to that of diazepam and nitrazepam and to that of chlordiazepoxide .These results confirm the pharmacological similarities existing between zopiclone and the benzodiazepines. |
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