Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization |
| |
| Authors: | M B Qumsiyeh M B Valentine D P Suttle |
| |
| Affiliation: | Department of Biochemical and Clinical Pharmacology, St. Jude Children's Research Hospital, Memphis 38101. |
| |
| Abstract: | The bifunctional enzyme uridine monophosphate (UMP) synthase catalyzes the last two steps in de novo pyrimidine biosynthesis. A genetic deficiency in the activity of this enzyme causes the inherited human disease orotic aciduria. We used a human cDNA probe to localize the gene for UMP synthase to human chromosome region 3q13 by the technique of in situ hybridization. |
| |
| Keywords: | |
|
