Distribution of acid and alkaline deoxyribonucleases in white and grey matter regions of growing and aging chick brain |
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Authors: | K Subba Rao K P Shrivastaw |
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Institution: | (1) Biochemistry Division, Department of Chemistry, Banaras Hindu University, 221 005 Varanasi;(2) School of Life Sciences, University of Hyderabad, 500 001 Hyderabad |
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Abstract: | The activities of acid and alkaline deoxyribonucleases in the white and grey matter areas of growing and old chick cerebrum
were measured. Two marker enzymes for glial cells, butyrylcholinesterase and carbonic anhydrase were also measured in these
regions. Higher specific activities of both butyrylcholinesterase and carbonic anhydrase were found in the white matter region
at all the stages studied. Acid and alkaline deoxyribonuclease activities were observed in both white and grey matter. The
decrease in the specific activity of acid deoxyribonuclease with advancement of age was more pronounced as compared to the
alkaline deoxyribonuclease Marked reduction in total acid deoxyribonuclease activity in white matter, beyond the age of 130
days, was observed. On the other hand, total alkaline deoxyribonuclease activity in both white and grey matter continued to
increase with age Further, the activity per mg of DNA also increased in white matter of the old brain. These results indirectly
suggest a continued role for alkaline deoxyribonuclease in glial cells formed at a later age. |
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Keywords: | Acid deoxyribonucleases alkaline deoxyribonucleases aging chick brain |
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