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Hotspots of mammalian chromosomal evolution |
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| Authors: | Bailey Jeffrey A Baertsch Robert Kent W James Haussler David Eichler Evan E |
| Institution: | (1) Department of Genetics, Center for Computational Genomics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA;(2) Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95064, USA;(3) Howard Hughes Medical Institute, 321 Baskin Engineering, University of California, Santa Cruz, CA 95064, USA; |
| Abstract: | BackgroundChromosomal evolution is thought to occur through a random process of breakage and rearrangement that leads to karyotype differences and disruption of gene order. With the availability of both the human and mouse genomic sequences, detailed analysis of the sequence properties underlying these breakpoints is now possible. |
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