Heterozygous female carriers of the marker-X-chromosome: IQ estimation and replication status of fra(X)(q) |
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Authors: | J Paul Ursula Froster-Iskenius W Móje E Schwinger |
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Institution: | (1) Institut für Humangenetik, Medizinische Hochschule Lübeck, Ratzeburger Allee 160, D-2400 Lübeck;(2) Klinik für Psychiatrie, Medizinische Hochschule Lübeck, Ratzeburger Allee 160, D-2400 Lübeck |
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Abstract: | Summary The IQ levels of 18 female carriers with the marker X chromosome were evaluated, and cytogenetic studies after BrdU incorporation were performed. A highly significant correlation between mental capacity and replication pattern of the X chromosomes could be demonstrated. Heterozygous females with normal intelligence showed a clear tendency to carry the fragile site at the late replicating X chromosome, while other female carriers with lower intelligence or mental impairment expressed their fragile site mainly with the early replicating X chromosome. This observation could be interpreted as an expression of Lyonisation. |
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