Identification of Wnt responsive genes using a murine mammary epithelial cell line model system |
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| Authors: | Email author" target="_blank">Lisa?TaneyhillEmail author Diane?Pennica |
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| Institution: | (1) Division of Biology, California Institute of Technology, Pasadena, CA, USA;(2) Molecular Oncology Department, Genentech, Inc., South San Francisco, CA, USA |
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| Abstract: | Background The Wnt/Wg pathway plays an important role in the developmental program of many cells and tissues in a variety of organisms.
In addition, many Wnts and components of their downstream signaling pathways, such as β-catenin and APC, have been implicated
in tumorigenesis. Over the past years, several genes have been identified as Wnt responsive, including c-myc, siamois, and cyclin D1. |
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