Biotransformation of 2-acetylthiophene by micromycetes |
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| Authors: | Françoise Seigle-Murandi Serge Krivobok Régine Steiman Georges-André Thiault Jean-Louis Benoit-Guyod |
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| Affiliation: | (1) Laboratoire de Botanique, Cryptogamie, Biologie Cellulaire et Génétique, GEDEXE UFR de Pharmacie, Université J. Fourier, Grenoble I, BP 138, F-38243 Meylan Cédex, France;(2) Produits Chimiques Auxiliaires et de Synthèse (PCAS), 23 Rue Bossuet, F-91160 Longjumeau, France;(3) Laboratoire de Toxicologie et Ecotoxicologie, GEDEXE, UFR de Pharmacie, Université J. Fourier, Grenoble I, BP 138, F-38243 Meylan Cédex, France |
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| Abstract: | Summary The biotransformation of 2-acetylthiophene by 800 strains of micromycetes has been investigated. Among them, 460 strains have been selected on solid media and cultivated in a liquid synthetic medium. Of these, 106 strains were able to completely deplete 2-acetylthiophene with or without production of intermediary metabolites. 2-Thienylglyoxylic acid was not detected but 72 strains produced 2-thiophenecarboxylic acid. Among them, eight strains have been selected for further optimization of this bioconversion. |
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