Serum prostaglandin F2α concentration in the carcinoid syndrome |
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Authors: | Jerome M. Feldman James W. Plonk James C. Cornette |
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Affiliation: | 1. Department of Medicine Duke University Medical Center and Durham Veterans Administration Hospital Durham, North Carolina 27701 USA;2. Fertility Research The Upjohn Company Kalamazoo, Michigan 49001 USA |
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Abstract: | Using specific radioimmunoassay procedures we measured prostaglandin F2α (PGF2α) and 13, 14-dihydro-15-keto prostaglandin F2α (PGF2α metabolite) in 12 patients with carcinoid tumors. Although PGF2α and PGF2α metabolite were each modestly elevated in 17% of the patients the magnitude of the elevation did not correlate with the symptoms of the carcinoid syndrome. The 24 hour urinary 5-hydroxyindoleacetic acid excretion showed a good correlation with carcinoid symptoms while the serum serotonin concentration showed a fair correlation with carcinoid symptoms. We conclude that serum elevation of PGF2α is not a frequent occurrence in patients with the carcinoid syndrome. |
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