Serum prostaglandin F2α concentration in the carcinoid syndrome |
| |
Authors: | Jerome M Feldman James W Plonk James C Cornette |
| |
Institution: | 1. Department of Medicine Duke University Medical Center and Durham Veterans Administration Hospital Durham, North Carolina 27701 USA;2. Fertility Research The Upjohn Company Kalamazoo, Michigan 49001 USA |
| |
Abstract: | Using specific radioimmunoassay procedures we measured prostaglandin F2α (PGF2α) and 13, 14-dihydro-15-keto prostaglandin F2α (PGF2α metabolite) in 12 patients with carcinoid tumors. Although PGF2α and PGF2α metabolite were each modestly elevated in 17% of the patients the magnitude of the elevation did not correlate with the symptoms of the carcinoid syndrome. The 24 hour urinary 5-hydroxyindoleacetic acid excretion showed a good correlation with carcinoid symptoms while the serum serotonin concentration showed a fair correlation with carcinoid symptoms. We conclude that serum elevation of PGF2α is not a frequent occurrence in patients with the carcinoid syndrome. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |