Antioxidative defense organization in retroperitoneal white adipose tissue during acclimation to cold—The involvement of l-arginine/NO pathway |
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| Authors: | Aleksandra Jankovi&#x , Biljana Buzad i&#x , Aleksandra Kora&#x , Vesna Petrovi&#x , Ana Vasilijevi&#x ,Bato Kora&#x |
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| Affiliation: | aDepartment of Physiology, Institute for Biological Research “Siniša Stankovic”, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia;bInstitute of Zoology, Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia |
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| Abstract: | - 1. Retroperitoneal white adipose tissue (RpWAT) antioxidative defense was investigated in untreated, l-arginine-treated and Nω-nitro-l-arginine methyl ester (l-NAME)-treated rats kept at 4±1 °C (1, 3, 7, 12, 21 and 45 days) and compared to control rats at 22±1 °C.
- 2. Cold-acclimation-induced RpWAT weight decrease was accompanied by a decline in glutathione level and increased activity of manganese superoxide dismutase (MnSOD), glutathione S-transferase (GST), catalase, glutathione peroxidase and glutathione reductase at different time-points.
- 3. l-arginine accelerated RpWAT weight decrease, the increase in MnSOD and GST activities and the prolonged increase of catalase, MnSOD and GST activities. l-NAME delayed cold-induced catalase activity increase and tissue weight decrease. Prolonged l-NAME-treatment had a similar effect on RpWAT as l-arginine.
- 4. Results suggest the involvement of l-arginine/NO pathway in RpWAT oxidative metabolic augmentation induced by cold-acclimation.
Keywords: White adipose tissue; Antioxidative defense; l-arginine; Nitric oxide; l-NAME; Cold |
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| Keywords: | White adipose tissue Antioxidative defense smCaps" >l-arginine Nitric oxide smCaps" >l-NAME Cold |
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