Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives |
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| Authors: | Theerachart Leepasert Manochehr Shahabi Karem Shanab Eva Schirmer Wolfgang Holzer Helmut Spreitzer Babette Aicher Gilbert Müller Eckhard Günther |
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| Institution: | 1. Department of Drug and Natural Product Synthesis, University of Vienna, Althanstraße 14, 1090 Vienna, Austria;2. Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand;3. AeternaZentaris GmbH, Weismuellerstrasse 50, 60314 Frankfurt, Germany |
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| Abstract: | A new series of substituted tri-/tetraazabenzo3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines. |
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| Keywords: | Anticancer compounds |
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