Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors |
| |
Authors: | Guohua Zhao Chet Kwon Aiying Wang James G Robertson Jovita Marcinkeviciene Rex A Parker Mark S Kirby Lawrence G Hamann |
| |
Institution: | Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08543-5400, USA |
| |
Abstract: | Synthesis and structure–activity relationship of a series of substituted piperidinyl glycine 2-cyano-4,5-methano pyrroline DPP-IV inhibitors are described. Improvement of the inhibitory activity and chemical stability of this series of compounds was respectively achieved by the introduction of bulky groups at the 4-position and 1-position of the piperidinyl glycine, leading to a series of potent and stable DPP-IV inhibitors. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|