In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe |
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| Authors: | Jun Zhou Guiyang Hao Hong Weng Yi-Ting Tsai David W Baker Xiankai Sun Liping Tang |
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| Institution: | 1. Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA;2. Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;3. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA |
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| Abstract: | To image implant-surrounding activated macrophages, a macrophage-specific PET probe was prepared by conjugating folic acid (FA) and 2,2′,2″,2?-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetracetic acid (DOTA) to polyethylene glycol (PEG) and then labeling the conjugate with Ga-68. In vivo PET imaging evaluations demonstrate that the probe is able to detect foreign body reactions, and more importantly, quantify the degree of inflammatory responses to an implanted medical device. These results were further validated by histological analysis. |
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