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Conjugation of l-NAME to prenyloxycinnamic acids improves its inhibitory effects on nitric oxide production |
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| Authors: | Salvatore Genovese Francesco Epifano Serena Fiorito Massimo Curini Mariangela Marrelli Francesco Menichini Filomena Conforti |
| Institution: | 1. Dipartimento di Farmacia, Università ‘G. D’Annunzio’ Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy;2. Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, Via del Liceo, 06132 Perugia, Italy;3. Department of Pharmacy and Health and Nutrition Sciences, University of Calabria, I-87036 Rende (CS), Italy |
| Abstract: | A series of 10 compounds resulting from the conjugation of O-prenylated naturally occurring benzoic and cinnamic acids to l-NAME were synthesized and tested together with the corresponding unprenylated parent molecule as anti-inflammatory agents for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophages. Results indicated that the coupling between O-geranyl and O-isopentenylcinnamic acids and l-NAME led to products with an enhanced activity when compared to the parent compounds. |
| Keywords: | Oxyprenylated natural cinnamic acids Nitric oxide Inflammation |
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