A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase |
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Authors: | Huanjie Guo Huanxin Zhao Yuichiro Kanno Wei Li Yanling Mu Xinzhu Kuang Yoshio Inouye Kazuo Koike Haipeng Jiang Hong Bai |
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Affiliation: | 1. Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China;2. School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China;3. Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 247-8510, Japan;4. Key Laboratory for Green Chemical Process of Education Ministry, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, Hubei 430073, PR China |
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Abstract: | Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a major cellular energy sensor and master regulator of metabolic homeostasis; thus, AMPK plays a central role in studies on diabetes and related metabolic diseases. From the rhizomes of Polygonatum odoratum (Mill.) Druce, six homoisoflavonoids (1–6) and one dihydrochalcone (7) were isolated, and the structures of polygonatones A–D (4–7) were elucidated by various spectroscopic analyses. Compounds 1–7 were evaluated for their effect on AMPK activation. The amount of active phosphorylated AMPK and acetyl-CoA carboxylase in rat liver epithelial IAR-20 cells increased when the cells were incubated with the aforementioned compounds. Specifically, (3R)-5,7-dihydroxyl-6-methyl-8-methoxyl-3-(4′-hydroxylbenzyl)-chroman-4-one (1), (3R)-5,7-dihydroxyl-6,8-dimethyl-3-(4′-hydroxylbenzyl)-chroman-4-one (2), (3R)-5,7-dihydroxyl-6-methyl-3-(4′-hydroxylbenzyl)-chroman-4-one (3), and polygonatone D (7) exhibited significant activation effects. |
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Keywords: | Homoisoflavonoids Dihydrochalcone AMPK activation |
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