Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity |
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| Authors: | Mutlu Dilsiz Aytemir Berrin Özçelik Gülşah Karakaya |
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| Affiliation: | 1. Dept. Pharm. Chem., Fac. Pharm., Hacettepe University, 06100 Ankara, Turkey;2. Dept. Pharm. Microbiol., Fac. Pharm., Gazi University, 06330 Ankara, Turkey |
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| Abstract: | In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum. |
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| Keywords: | Synthesis Chlorokojic acid Mannich base Cytotoxicity Antidermatophytic activity |
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