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Novel cancer-targeting SPECT/NIRF dual-modality imaging probe 99mTc-PC-1007: Synthesis and biological evaluation |
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| Authors: | Yi Zhang Li Xiao Kosta Popovic Xiuzhen Xie Mahendra D Chordia Leland WK Chung Mark B Williams Wei Yue Dongfeng Pan |
| Institution: | 1. Department of Radiology and Medical Imaging, University of Virginia, Rm 263, 480 Ray C. Hunt Drive, Snyder Building, Charlottesville, VA 22908, USA;2. Uro-Oncology Research, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;3. Department of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA 22908, USA |
| Abstract: | Synthesis, characterization, in vitro and in vivo biological evaluation of a heptamethine cyanine based dual-mode single-photon emission computed tomography (SPECT)/near infrared fluorescence (NIRF) imaging probe 99mTc-PC-1007 is described. 99mTc-PC-1007 exhibited preferential accumulation in human breast cancer MCF-7 cells. Cancer-specific SPECT/CT and NIRF imaging of 99mTc-PC-1007 was performed in a breast cancer xenograft model. The probe uptake ratio of tumor to control (spinal cord) was calculated to be 4.02 ± 0.56 at 6 h post injection (pi) and 8.50 ± 1.41 at 20 h pi (P < 0.0001). Pharmacokinetic parameters such as blood clearance and organ distribution were assessed. |
| Keywords: | Breast cancer Dual-modality Heptamethine cyanine dye SPECT 99m-Technetium Near infrared fluorescence |
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